Generic Name
Amantadine sulphate
Amantadine sulphate.............100 mg
PK-Merz is indicated in case of:
  • Treatment of all symptoms of Parkinson's disease such as rigidity, tremor, hypokinesia and akinesia.
  • Extrapyramidal side effects of neuroleptics and other drugs with similar modes of action, such as early dyskinesia, akathisia and parkinsonian symptoms.
  • Residual symptoms and complaints after stereotactic operations.
PK-Merz must not be used in patients with:
  • Hypersensitivity to amantadine, or to any of the other constituents of the medicinal product.
  • Severe heart failure. Patients with known cardiovascular conditions must remain under regular medical monitoring during treatment with PK-Merz tablets such as cardiomyopathies, myocarditis, grade II or III AV-block, known prolonged QT interval or simultaneous treatment with drugs that prolong the QT interval.
Drug Interactions
In concomitant administration of amantadine and memantine, the latter can potentiate the effects and side effects of the former.
Side Effects/Adverse Effects
Uncommonly, anticholinergic side effects rarely occur.
In very rare cases, increased photosensitivity has been reported.
Pregnancy & Lactation
Amantadine should only be used after careful assessment of the risks and benefits and only where absolutely necessary.
Dosage & Administration
Unless otherwise prescribed, 1 tablet is to be taken per day for the first three days to be increased to a regular dosage of 2 tablets per day.
It is possible to increase the dosage on a weekly interval of 1 tablet.
In special cases, the dose may be increased to 5-6 tablets day.
A maximum daily dosage of 6 tablets should not be exceeded, and should be divided into three individual sub-doses per day.
The final daily dose should be taken in the afternoon (before 4 PM).
Gradual discontinuation of PK-Merz tablets is recommended to avoid sudden deterioration of the patient's condition.
In elderly patients, particularly those with stages of agitation and confusion or delirium syndromes, treatment should be commenced at a lower dose.
In patients previously treated with amantadine sulphate infusion solution, a higher starting dose can be chosen.
In the even of an acute worsening of Parkinsonian symptoms in the snse of akinetic crisis, amantadine sulphate infusion treatment should be administered.
As with other drugs used in the treatment of Parkinsonian syndrome, on commencement of treatment there may conseuquently be a further deterioration in the ability to drive and operate machinery over and above any impairment caused by the condition itself. This impairment is further intensified in association with alcohol.
Do no store above 25°C.
Box of 3 strips of 10 tablets each.
Merz Pharmaceuticals
Date Added/Updated
15th June 2012 2:57 pm


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